IV Vitamin C Infusion helps EBV (Mononucleosis) Infection

IV Vitamin C infusion helps EBV (Mononucleosis) infection


The article below suggests an improvement in the EBV antigens in response to treatment with IV Vitamin C infusion. It also suggests that Vitamin D is beneficial. At Tri Cities Health, we offer customized IV Infusions to address symptoms associated with EBV/Mono such as fatigue, arthralgia, and headache. Most patients experience immediate relief from many of these symptoms after the first infusion.

Read below for research study details:


Med Sci Monit. 2014; 20: 725–732.

Published online 2014 May 3. doi:  10.12659/MSM.890423

PMCID: PMC4015650

Effect of high dose vitamin C on Epstein-Barr viral infection

Nina A. MikirovaA,C,D,E and Ronald HunninghakeA



Many natural compounds were tested for the ability to suppress viral replication. The present manuscript details an analysis of high dose vitamin C therapy on patients with EBV infection.


The data were obtained from the patient history database at the Riordan Clinic. Among people in our database who were treated with intravenous vitamin C (7.5 g to 50 g infusions) between 1997 and 2006, 178 patients showed elevated levels of EBV EA IgG (range 25 to 211 AU) and 40 showed elevated levels of EBV VCA IgM (range 25 to 140 AU). Most of these patients had a diagnosis of chronic fatigue syndrome, with the rest being diagnosed as having mononucleosis, fatigue, or EBV infection.


Our data provide evidence that high dose intravenous vitamin C therapy has a positive effect on disease duration and reduction of viral antibody levels.

Plasma levels of ascorbic acid and vitamin D were correlated with levels of antibodies to EBV. We found an inverse correlation between EBV VCA IgM and vitamin C in plasma in patients with mononucleosis and CFS meaning that patients with high levels of vitamin C tended to have lower levels of antigens in the acute state of disease.

In addition, a relation was found between vitamin D levels and EBV EA IgG with lower levels of EBV early antigen IgG for higher levels of vitamin D.


The clinical study of ascorbic acid and EBV infection showed the reduction in EBV EA IgG and EBV VCA IgM antibody levels over time during IVC therapy that is consistent with observations from the literature that millimolar levels of ascorbate hinder viral infection and replication in vitro.

MeSH Keywords: Administration, Intravenous – methods, Ascorbic Acid Deficiency – therapy, Epstein-Barr Virus Infections – history, Vitamin D – blood